Decrease of cell proliferation, cytotoxicity, and proapoptotic effects induced by CIGLI, TRO, ROSI, and PIO has been reported in a variety of cell lines (sarcoma, melanoma, glioblastoma, breast carcinoma, colorectal cancer, gastric cancer, pancreatic cancer, prostate, bladder cancer, hepatic cancer, thyroid cancer, ovarian cancer, endometrial cancer, and lung cancer cells), which will not be listed in detail. The gene discussed is TRO; the disease is ovarian carcinoma.