In addition to the Notch1, it degrades various proteins, important for the T-ALL pathogenesis such as Myc and cyclin E. The FBXW7 mutations result in inability to bind to its target proteins (Notch1) or bind its targets but fail to tag them for degradation (Myc), in both cases prolonging their half-life. Here, MYC is linked to acute lymphoblastic leukemia.