hERG1 can increase oncogenic potential in leukemias by affecting one of several ways facilitating leukemogenesis: (1) balance between proliferation and cell death; (2) invasiveness, depending on the fine balance between adhesion and motility, the latter being in turn dependent on polarized volume changes; (3) resistance to chemotherapy [127, 180]; (4) angiogenesis, via secretion of vascular endothelial growth factor (VEGF) and positively feedbacked microvesicles release [181, 182]. Here, KCNH2 is linked to leukemia.