Among the targets, activated by the Notch1 in the T-ALL, transcriptional factors HES1, HERPI 1&2, and EGF-containing fibulin—like extracellular matrix protein 1 (EFEMP1), vascular endothelial growth factor VEGF, inhibitor of DNA binding 1 (ID1), and SnoRNAs of the box H/ACA quantitative accumulation (SHQ1), immune associated nucleotide 4 like 1 IAN4L1/GIMAP5, and coreceptor CD28 were also reported [46, 47]. Here, HES1 is linked to acute lymphoblastic leukemia.