IGF-2R deserves a mention since studies implicate that the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-2R) functions in the intracellular trafficking of lysosomal enzymes, the activation of the potent growth inhibition transforming growth factor beta 2, and the degradation of IGF2 (which are overexpressed in tumours). Here, IGF2R is linked to neoplasm.