IGF2 and neoplasm: IGF-2R deserves a mention since studies implicate that the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-2R) functions in the intracellular trafficking of lysosomal enzymes, the activation of the potent growth inhibition transforming growth factor beta 2, and the degradation of IGF2 (which are overexpressed in tumours).