IGFBP-6. As recently reviewed [82], IGFBP-6 is also known to have inhibitory effects in cancer by blocking IGF signalling, extraordinarily IGFII, but there is evidence where in some circumstances it may have oncogenic actions stimulating migration [179] and proliferation [70] which is mechanistically stronger than for IGFBP-4. This evidence concerns the gene IGF2 and cancer.