Blocking the Notch signaling in FSGS model established in SCID mice injected with adriamycin ameliorated proteinuria and prevented podocyte loss in the early stage (7 days) of glomerular insult; however, it hampered CD24+CD133+ PECs proliferation during the later reparative stage with exacerbating proteinuria and glomerulosclerosis [46]. Here, PROM1 is linked to focal segmental glomerulosclerosis.