This will be achieved by constructing and utilizing a CXCL12-KDEL fusion gene expression vector (CXCL12-KDEL-pIRES2-EGFP) to block the CXCL12-CXCR4 biological axis and intracellularly sequester CXCR4, in order to inhibit HNSCC metastasis. Here, CXCL12 is linked to head and neck squamous cell carcinoma.