The results obtained by quantitative methods in other studies showed HER2/neu oncoprotein to be more significantly expressed in the malignant group compared to the benign and normal groups [54], and they concluded that the quantitative assessment of HER2/neu expression in malignant tumors aided by other proliferation markers such as synthetic phase fraction (SPF), DNA index (DI), and ploidy is useful in selecting patients for more aggressive treatment or for predicting outcome. The gene discussed is ERBB2; the disease is cancer.