SHBG and breast carcinoma: Prospective cohort studies showed about a twofold increase in breast cancer risk among postmenopausal women who had higher production of various sex steroid, including dehydroepiandrosterone sulfate (DHEAS), testosterone, estrone, and total estradiol (E2) and breast cancer risk was inversely correlated with the expression of steroid hormone binding globulin (SHBG) [8].