Presence of K-ras wild type gene predicts response to epidermal growth factor receptor (EGFR) monoclonal antibodies such as cetuximab or panitumumab, and they are usually combined with FOLFIRI (or FOLFOX in the case of panitumumab) in the treatment of metastatic colorectal cancer [4, 5]. This evidence concerns the gene EGFR and metastatic colorectal cancer.