TLR8 and melanoma: Since different studies have demonstrated that mouse TLR8 is a functional receptor, as reviewed recently 40, MT-ret/AAD C57BL/6 humanized HLA-A*0201 transgenic mice 41, expressing the HLA-A*0201 extracellular domains fused to the H2-D transmembrane domain and spontaneously developing melanoma, could even more accurately allow the investigation of TLR8 agonist-treated specific CTL effects on melanoma development control.