Moreover, this feature could be especially positive in the case of well-established autoimmune-related neurodegenerative diseases such as Multiple Sclerosis (MS) or Acute Motor Axonal Neuropathy, where elevated levels of specific IgM and IgG antibodies directed against certain self antigens have been shown to contribute to disease onset and progression 49–53. The gene discussed is CD40LG; the disease is multiple sclerosis.