CD4 and neurodegenerative disease: Because of the pivotal participation of CD4+ T cells in the development of synucleinopathies and other misfolding neurodegenerative diseases associated to chronic inflammation, we firstly compared the impact of immunizing mice with vehicle, αSyn, Hsp70, or the αSyn/Hsp70 combination, on the CD4+ cell populations within total splenocytes (Supporting Information Fig. S1).