AGT and hypertensive disorder: Several lines of evidence suggest that multiple NADPH oxidases are likely involved in a number of vascular pathologies, including Angiotensin II- (AngII-) induced hypertension and hypertrophy, serum-induced proliferation and platelet derived growth factor- (PDGF-) induced migration in SMCs, abnormal vascular growth and inflammation, and atherosclerosis [23, 33, 34].