Abnormal AR activity is associated with various pathogeneses such as male infertility, androgen-insensitivity syndrome (AIS), polycystic ovarian syndrome (PCOS), spinal and bulbar muscular atrophy (SBMA), rheumatoid arthritis, hirsutism, baldness, acne, breast cancer, and prostate cancer (PCa). The gene discussed is AR; the disease is polycystic ovary syndrome.