Abnormal AR activity is associated with various pathogeneses such as male infertility, androgen-insensitivity syndrome (AIS), polycystic ovarian syndrome (PCOS), spinal and bulbar muscular atrophy (SBMA), rheumatoid arthritis, hirsutism, baldness, acne, breast cancer, and prostate cancer (PCa). This evidence concerns the gene AR and Familial prostate cancer.