COX-2 has been implicated in the growth and progression of a variety of human cancers, 5-LOX and FLAP play a vital role in tumor cells growth related signal transduction and can stimulate oncogene expression, and 12-LOX may be responsible for the adhesion, invasion, and metastasis of cancer cells and also can promote tumor angiogenesis [30]. This evidence concerns the gene ALOX5 and neoplasm.