Moreover, the chronic exposition to inflammatory conditions such as natural history of aneurysmal disease [135–137] can determine failure of SMC recruitment and migration along developing vessels can lead to vascular instability and regression, an event that is likely due in part to the ability of these cells to secrete and organize extracellular matrix-containing basement membranes and elastin [18, 138–140]. Here, ELN is linked to Vascular dilatation.