NFKB1 and cancer: Multiple mechanisms have been proposed for gambogic acid-induced anticancer activities, including the induction of apoptosis [19], suppression of telomerase activity [21], induction of cell-cycle arrest [22], inhibition of cancer metastasis and angiogenesis [20, 23], inhibition of topoisomerase IIα activity [24] and inhibition of the NF-κB signaling pathway [25].