With sarcopenia, a 33% reduction in circulating IGF-I (Benbassat et al., 1997) and a 45% decline in SkM-derived IGF-I mRNA are observed in older (70 ± 0.3 years) vs. younger (20 ± 0.3 years) human males (Leger et al., 2008). This evidence concerns the gene IGF1 and sarcopenia.