Furthermore, we also found that icaritin was able to significantly decrease the levels of serum IL-6 and IgE in myeloma-bearing mouse, supporting that icaritin plays a critical role in anti-myeloma effect by inhibiting the activation of p-JAK2, p-STAT3, down-regulating the expression of VEGF and reducing the secretion of IL-6. Here, VEGFA is linked to plasma cell myeloma.