The LES TCR was demonstrated to bind endothelial protein C receptor (EPCR).47 EPCR exhibits sequence and structural homology with the MHC-like protein family CD1, and can present phospholipids bound in the antigen-presenting groove.48 EPCR plays a dual role in cancer, as it can both promote and inhibit metastases, presumably depending on whether it is expressed on tumour cells or endothelium (reviewed in Mohan Rao et al.49). The gene discussed is PROCR; the disease is cancer.