MSH2 and Familial prostate cancer: Unsurprisingly, defects in hMSH2 have been reported in various tumour histologies including lung, colon, breast and prostate cancers.52 Although hMSH2 is normally restricted to the nucleus, it can be translocated during cellular stress.53 Recent studies have demonstrated that hMSH2 can be a ligand for some Vδ2 γδ T cells when it is ectopically expressed, inducing cytotoxicity and IFN-γ production.54 Surface expression of hMSH2 can be induced by Epstein-Barr virus (EBV) infection,54 oxidative stress and proinflammatory cytokines such as IL-18 corroborating its role in generalised stress.