CD1A and neoplasm: The LES TCR was demonstrated to bind endothelial protein C receptor (EPCR).47 EPCR exhibits sequence and structural homology with the MHC-like protein family CD1, and can present phospholipids bound in the antigen-presenting groove.48 EPCR plays a dual role in cancer, as it can both promote and inhibit metastases, presumably depending on whether it is expressed on tumour cells or endothelium (reviewed in Mohan Rao et al.49).