Our observations in PCa cells add another level of complexity in terms of PERK signaling effects on proliferation versus apoptosis: Whereas PERK activation and thus eIF2α phosphorylation is downregulated, downstream targets of this pathways, ATF4 and CHOP, were increased at the protein level upon androgen stimulation (Fig2G). The gene discussed is EIF2A; the disease is posterior cortical atrophy.