Global gene expression profiling experiments in androgen-treated PCa cells have shown changes in the expression of some ER stress-associated genes, such as N-myc downstream-regulated gene 1 protein (NDRG1), protein disulfide isomerase-related protein (PDIR), homocysteine-responsive ER-resident ubiquitin-like domain member 1 protein (HERPUD1), and oxygen-regulated protein 150 (ORP150) (Segawa et al, 2002). The gene discussed is NDRG1; the disease is posterior cortical atrophy.