These findings are similar to those provoked by cardiac Mfn2 deficiency that interrupts PINK1/Parkin signaling by deleting the mitochondrial Parkin receptor (Chen & Dorn, 2013; Song et al, 2014) and are striking in their contrast to the rapidly progressive and lethal cardiomyopathy induced by complete interruption of mitochondrial fusion (combined Mfn1 and Mfn2 gene ablation) (Chen et al, 2011; Papanicolaou et al, 2012). This evidence concerns the gene MFN2 and cardiomyopathy.