When pNF-κB-Luc transfectants were treated with Andro (5 μM or 25 μM), both basal NF-κB-dependent transcriptional activity and TNF-α-induced NF-κB transcriptional activity have been significantly reduced in NPC cell lines including HK1 (P = 0.0054 and 0.0029, resp). The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.