CD32 negatively regulates IgG production by B cells [29]; CD163 is associated with a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis, and Hodgkin lymphoma [30, 31], while CD195 functions as a chemokine receptor and is involved in recruitment of immunocytes, especially T cells, to site of infection [32]. The gene discussed is CCR5; the disease is macrophage activation syndrome.