EZH2 and hepatocellular carcinoma: Moreover, Ezh2 was found to activate the β-catenin signaling by epigenetic repression of different negative regulators of Wnt pathway (e.g., AXIN2, NKD1, and PRICKLE1) implying a control on cellular proliferation; downregulation of Ezh2, indeed, reduced HCC cell growth [44].