In this context, we hypothesize that targeting the SST with pasireotide, a ligand with high affinity for SST5, might result in better sensitivity for occult EAS, knowing that the expression of SST5 mRNA in pituitary adenoma corticotrophs is five- to ten-fold higher than that of SST2 mRNA (21). Here, SSTR2 is linked to pituitary gland adenoma.