The rate was similar when those with one mild symptom or no previous exposure and positive confirmatory tests were excluded (n remaining = 1767; rate of AE: 13.3%, 95% CI, 12.2, 14.4) and when only those with a positive food challenge, history of anaphylaxis, or a convincing history and a SPT ≥ 8 mm or a peanut-specific IgE ≥ 15 kU/L were included (n = 1541; rate of AE: 13.5% CI 12.4, 14.8). This evidence concerns the gene IGHE and anaphylaxis.