The essential nature of CSQ1 is illustrated in CSQ1-null mice, which exhibit increased susceptibility to stress in a similar manner to exertional/environmental heat stroke and to human malignant hyperthermia (MH) a life-threatening hypermetabolic disorder induced by treatment with volatile anesthetics and the muscle relaxant succinylcholine [10,47,48]. This evidence concerns the gene CASQ1 and Heat Stroke.