Among the upregulated genes, Hspa1b, Ccl2, Cxcl2, Ccl3, Serpina3n, Timp1, H19, Hspb1, Ccl20, and Cxcl1 were found to demonstrate significant upregulation in pathological phase of ischemic stroke (see Table 2). This evidence concerns the gene CXCL2 and ischemic stroke.