Among the downregulated genes, Gpr88, Rgs9, Enthd1, Olr59, P2ry12, Degs2, Pde10a, Neu2, Adora2a, and Slc22a6 were found to demonstrate significant downregulation in pathological phase of ischemic stroke (see Table 8). This evidence concerns the gene PDE10A and ischemic stroke.