Among the downregulated genes, Gpr88, Rgs9, Enthd1, Olr59, P2ry12, Degs2, Pde10a, Neu2, Adora2a, and Slc22a6 were found to demonstrate significant downregulation in pathological phase of ischemic stroke (see Table 8). Here, NEU2 is linked to ischemic stroke.