Among the downregulated genes, Gpr88, Rgs9, Enthd1, Olr59, P2ry12, Degs2, Pde10a, Neu2, Adora2a, and Slc22a6 were found to demonstrate significant downregulation in pathological phase of ischemic stroke (see Table 8). Here, P2RY12 is linked to ischemic stroke.