Among the upregulated genes, Hspa1b, Ccl2, Cxcl2, Ccl3, Serpina3n, Timp1, H19, Hspb1, Ccl20, and Cxcl1 were found to demonstrate significant upregulation in pathological phase of ischemic stroke (see Table 2). Here, CXCL1 is linked to ischemic stroke.