In the issue of Free Radical Biology and Medicine, a controlled study [6] has shown that topical application of superoxide dismutase (SOD) fused with the TAT peptide (TAT-SOD), to various acupoints along the meridian lines used in acupuncture to treat obesity, leads to significant weight loss. The gene discussed is SOD1; the disease is obesity due to melanocortin 4 receptor deficiency.