Most prevalent Class II mutations under AML are translocation between RUNX1 (CBFα) gene on chromosome 21, ETO (or MTG8) gene on the 8 chromosome t(8;21) (q22;q22) [5], and inversion inv16 (CBFβ-MYH11) (p13q22) [6]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.