IL-22 has been shown to contribute to allergic asthma during the sensitization phase [17] and to promote lung immunopathology during fungal allergy [47], but it can also inhibit antigen-induced eosinophil airway inflammation through inhibition of IL-25 [48], of IL-10 [49], or during the challenge phase [17]. The gene discussed is IL25; the disease is allergic asthma.