Therefore, the increase in serum AFP level is significantly different in Arg/Arg (6076.12 ± 2629.01) when compared with Gly/Gly (778.55 ± 25.84) (p = 0.018), and this could be another marker for early diagnosis of HCC on the basis of genetic polymorphism of FGFR4 at rs351855. This evidence concerns the gene FGFR4 and hepatocellular carcinoma.