Enrichment analysis indicated that targeting xCT in this manner resulted in upregulated expression of a class of genes that may function to promote PEL cell survival in part by preventing apoptosis and/or programmed cell death, implying that in addition to its natural function as amino acid transporter, xCT also acts as a global regulator of down-stream effector proteins involved in tumor cell survival. Here, SLC38A7 is linked to neoplasm.