Therefore, in the current study we used Illumina human microarray analysis to interrogate changes in the transcriptional profiles of genes in 3 KSHV+ PEL cell-lines treated with the xCT selective inhibitor, SASP, which led to identification of a number of novel xCT-regulated downstream genes important to PEL survival or chemoresistance. Here, SLC7A11 is linked to primary effusion lymphoma.