E2F3 and neoplasm: Moreover, miR-503 has been widely described in the literature as an anti-tumor miRNA that regulates the expression of key cell cycle proteins, such as CDC25A and cyclins D1 and E1, as well as cell proliferation via E2F3 and PI3K regulation and the apoptosis status via BCL-2 inhibition [6, 25-27, 33, 34].