Because ASXL1 is a key regulator of the polycomb repressive complex 2 (PRC2), it is possible that AML carrying alterations of other genes involved in methylation marks via PRC2 and myeloid transformation such as EZH2 [27, 28], JARID2 [29] or BAP1 [30, 31] could share characteristics of ASXL1-mutated AML. The gene discussed is EZH2; the disease is acute myeloid leukemia.