In fact, NDRG1 plays a significant role in reducing cancer cell migration by inhibiting the Rho-associated coiled-coil containing protein kinase1 (ROCK1)/phosphorylated myosin light chain2 (pMLC2) pathway, which is downstream of the Rho family of small GTPases, to regulate F-actin polymerization and organization [31]. This evidence concerns the gene NDRG1 and cancer.