Initially, to elucidate the molecular role of NDRG1 on regulating the activation of c-Src, we utilized two established models, namely DU145 prostate cancer cells (Figure 1B) and HT29 colon cancer cells (Figure 1C) that stably over-express exogenous human NDRG1 (denoted as “NDRG1”). Here, NDRG1 is linked to malignant colon neoplasm.