TMPRSS6 and Iron deficiency anemia: The Tmprss6 KO mouse model is characterized by iron deficient anemia, as assessed by low hemoglobin (data not shown), low LIC (S6A Fig), low TS (S6B Fig), due to hyperactivation of the BMP-SMAD pathway [24] and inappropriately high hepcidin levels (S6C Fig and [18]).