In the deoxycorticosterone acetate-salt (DOCA-salt) model of neurogenic hypertension, overexpression of angiotensin-converting enzyme 2 (ACE2) attenuates hypertension and reverses DOCA-salt-induced increases in PVN extracellular signal regulated kinase (ERK) and cyclooxygenase 1-mediated inflammation [18]. Here, ACE2 is linked to hypertensive disorder.