GDAP1 and motor neuron disorder: This phenotype may be interpreted in two ways: (i) changes in motor neurons might be either a compensatory response to the abnormal function of nerves that are not altered enough to show pathological changes, or lack of GDAP1 in mice may be expressed primarily as a motor neuron disease; or (ii) both proximal lesions at neuronal somas and distal changes at NMJs may be the consequence of mitochondrial dysfunction in dendrites and distal synapsis where mitochondria are more present.