HLA-C and AIDS: The impact of the MHC in response to human immunodeficiency virus (HIV) is well recognized, with class I alleles like HLA-B*35:01 leading to rapid onset of AIDS while HLA-B*57:01 and HLA-B*27:05 confer long-term non-progression (Carrington et al., 1999; Goulder and Walker, 2012; International HIV Controllers Study et al., 2013).