The COL1A1 and NCAM1 mRNA expression showed 3.10 ± 1.08 fold up-regulation and 0.37 ± 0.02 fold down-regulation in tumor tissues vs. normal ones (p < 0.01), while Western blot data showed a clear difference between the relative protein density of COL1A1 in cancer tissues (0.92 ± 0.02) vs. adjacent normal tissues (0.29 ± 0.01; p < 0.01), while expression of NCAM1 in cancer tissues (0.11 ± 0.002) vs. normal ones (0.85 ± 0.05) (p< 0.01, Fig 7). This evidence concerns the gene COL1A1 and neoplasm.