We next investigated the capacity of murine whole blood cells to release S100A8/A9 in the systemic compartment following infection and found that whole blood from WT mice stimulated for 4 hours with S. Typhimurium released S100A8/A9 complexes in a dose dependent manner (P = 0.016; Fig 2C). The gene discussed is IGKV1D-22; the disease is infection.