Examples of tumor-related overexpressed genes which become promoter hypomethylated during carcinogenesis includes, but not limited to, Sonic Hedgehog [67], P-cadherin [68], and CDH3 [69], as well as MATN4 and CTSL2 [52,53], supporting the data reported here for BST-2. The gene discussed is BST2; the disease is neoplasm.