They also were clustered around genes bound by EZH2 in germinal center B-cells (P=3 × 10−29) and hESCs (P=1 × 10−23).20, 29 These results show that the PRC2 is bound normally in B-cells near CpGs that undergo hypermethylation during disease progression in patients with CLL. The gene discussed is EZH2; the disease is B-cell chronic lymphocytic leukemia.