Figure 4a shows the results of the IPA in a proposed model of the dysfunctional BME in AML. Concordant with decreased MCP-1 in our cytokine profiling data, Figure 4b illustrates a gene expression network that contributes to inhibition of MCP-1 (chemokine (C-C motif) ligand 2 (CCL2)). See Supplementary Table 1 for description and function of the top 10 upregulated and downregulated molecules and Supplementary Figure 3 for representative pathway network showing upregulation of the transcription factors, FOS and MYB in AML. The gene discussed is MYB; the disease is acute myeloid leukemia.