Later hsFlt-1-e15a expression was found to be up-regulated in the trophoblast by hypoxia [254], and hsFlt-1-e15a isoform to be the most abundant sFlt-1 isoform in the placenta in women with preeclampsia, corresponding to 81.69% of the FLT1 transcripts [94,154,155]. Here, FLT1 is linked to preeclampsia.