VEGFA and preeclampsia: Based on these facts, since preeclampsia is a primate-specific disease and sFlt-1-e15a is a primate-specific isoform, it was speculated that hsFlt-1-e15a may have yet unidentified biological properties which may be critical in the development of preeclampsia [94,254] Indeed, the unique C-terminus of hsFlt-1-e15a includes a polyserine stretch [94,250], and hsFlt-1-e15a exhibits strong VEGF inhibitor properties [94].