TNF and Hypertension: RCTs in patients with RA have been inconsistent, with some showing significant and others nonsignificant association between hypertension and anti-TNF therapy.19–23 In addition, RCTs have been too brief or too small to accumulate enough hypertension events, and data concerning hypertension with anti-TNF agents used in different clinical trials have not been evaluated, the association between anti-TNF agent therapy for RA and hypertension is uncertain.