The pooled OR of hypertension demonstrated that anti-TNF antibody significantly increased the risk of hypertension comparing with control with an OR of 1.8896 (95% CI: 1.35–2.65; P value = 0.0002, Figure 3) according to a fixed-effects model (I2 = 0%, P = 0.5579).4,5,19–23,34–37 To validate the relative risk of hypertension between anti-TNF antibody and control groups, we also performed sensitivity analysis to examine the stability and reliability of pooled OR by sequential omission of individual studies. The gene discussed is TNF; the disease is Hypertension.