F2 and neoplasm: In univariate analysis, reasons for discontinuation of sorafenib, ECOG, Child–Pugh class, concurrent VI and Mets, tumor size, serum bilirubin, creatinine, albumin, prothrombin time, and AST levels at the time of PD, PD within 4 months, development of intrahepatic growth, and new extrahepatic lesion were factors associated with PPS (Table 5).