SDHAF2 and hereditary disease: Considering the gene function of peak associated ORFs, it is of interest that 14 of such ORFs have human orthologs involved in Mendelian diseases, detected from the Database of Human Disease Orthologs [50]; among these are the YPL164C gene, whose human ortholog gene MLH3 encodes the DNA Mismatch Repair Protein Mlh32 associated to HNPCC or Hereditary nonpolyposis colorectal cancer, the YOL071W (SDH5) gene whose human ortholog SDHAF2 (alias PGL2) is associated to familial paragangliomas 2 and the YPL204W gene whose human ortholog CSNK1A1 is associated to familial adenomatous polyposis.