Interestingly, while there was no difference in macroscopic metastatic incidence between Recql4+/+ and Recql4fl/fl tumour-bearing mice (including comparison to larger historic cohorts within the same facility), the Recql4fl/+ mice presented with an increased metastatic incidence at autopsy compared to either the Osx-Cre p53fl/flRecql4+/+ or Osx-Cre p53fl/flRecql4fl/fl mice. This evidence concerns the gene RECQL4 and neoplasm.