Genes that are highly over-expressed include ENO2, HK2, PFKP, SLC2A3, PDK1, and SLC16A1. Genes that are highly under-expressed include ALDOB, PKLR, PFKFB2, G6PC, PCK1, FBP1, PC, and SUCLG1. It cannot be overemphasized that these results apply only to CCRCC and not to other cancers. The gene discussed is PKLR; the disease is cancer.